Overland (3-2, 0-1) struck on their opening drive thanks to Mallan Robinson’s 29-yard touchdown run.
Cherry Creek (3-2, 1-0) dominated from there. Tahj Willingham ran 21 times for 159 yards and a pair of touchdowns.
Overland quarterback Austin Conway, who scored seven touchdowns in the Trailblazers’ last game at Poudre, was picked off three times.
Cherry Creek hosts Cherokee Trail next Friday at 7. Overland visits Grandview next Friday at 7 as well.